In vivo gastric detection of α-synuclein inclusions in Parkinson's disease.
Identifieur interne : 000211 ( Main/Exploration ); précédent : 000210; suivant : 000212In vivo gastric detection of α-synuclein inclusions in Parkinson's disease.
Auteurs : Álvaro Sánchez-Ferro [Espagne] ; Alberto Rábano ; María José Catalán ; Fernando Canga Rodríguez-Valcárcel ; Servando Fernández Díez ; Jaime Herreros-Rodríguez ; Elvira García-Cobos ; Marina Mata Álvarez-Santullano ; Lydia L Pez-Manzanares ; Antonio J. Mosqueira ; Lydia Vela Desojo ; Juan José L Pez-Lozano ; Eva L Pez-Valdés ; Rafael Sánchez-Sánchez ; José Antonio Molina-ArjonaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
α-Synuclein inclusions have been identified in the brain and some parts of the enteric nervous system in Parkinson's disease cases. We aimed to assess these inclusions in gastric mucosa samples from patients with symptomatic Parkinson's disease. Random biopsies were performed by gastroscopy in 28 patients with Parkinson's disease and in 29 age- and sex-matched controls. Gastroscopy was performed to start enteral levodopa (L-dopa) therapy in cases and for diagnostic purposes in controls (gastroesophageal reflux, anemia, and abdominal pain were the main indications). The clinical definition of cases and controls was made a priori. Six controls had data suggestive of "mild presymptomatic parkinsonism". Biopsy specimens were immunostained for α-synuclein. The neuropathological diagnosis was established post hoc. No differences were found in the baseline characteristics of the groups. Positive fibers for the α-synuclein protein were observed in 17 of 28 (60.7%) Parkinson's disease patients, 1 of 23 controls (4.3%), and 1 of 6 (16.7%) cases of incident "mild presymptomatic parkinsonism." Neuropathological diagnosis based on α-synuclein immunostaining showed a sensitivity of 85% (95% confidence interval [CI] 62.1-96.8), specificity of 95% (95% CI 76.2-99.9) and area under the receiver operating characteristics curve (AUC) of 0.90 (95% CI 0.80-1.00). No adverse events occurred. Detection of α-synuclein inclusions in the gastric mucosa is a useful and safe tool providing in vivo evidence of the underlying neurodegenerative peripheral involvement linked to Parkinson's disease. Further studies are warranted to determine its pathophysiological implications.
DOI: 10.1002/mds.25988
PubMed: 25113060
Affiliations:
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Mosqueira</name></author><author><name sortKey="Vela Desojo, Lydia" sort="Vela Desojo, Lydia" uniqKey="Vela Desojo L" first="Lydia" last="Vela Desojo">Lydia Vela Desojo</name></author><author><name sortKey="L Pez Lozano, Juan Jose" sort="L Pez Lozano, Juan Jose" uniqKey="L Pez Lozano J" first="Juan José" last="L Pez-Lozano">Juan José L Pez-Lozano</name></author><author><name sortKey="L Pez Valdes, Eva" sort="L Pez Valdes, Eva" uniqKey="L Pez Valdes E" first="Eva" last="L Pez-Valdés">Eva L Pez-Valdés</name></author><author><name sortKey="Sanchez Sanchez, Rafael" sort="Sanchez Sanchez, Rafael" uniqKey="Sanchez Sanchez R" first="Rafael" last="Sánchez-Sánchez">Rafael Sánchez-Sánchez</name></author><author><name sortKey="Molina Arjona, Jose Antonio" sort="Molina Arjona, Jose Antonio" uniqKey="Molina Arjona J" first="José Antonio" last="Molina-Arjona">José Antonio Molina-Arjona</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">α-Synuclein inclusions have been identified in the brain and some parts of the enteric nervous system in Parkinson's disease cases. We aimed to assess these inclusions in gastric mucosa samples from patients with symptomatic Parkinson's disease. Random biopsies were performed by gastroscopy in 28 patients with Parkinson's disease and in 29 age- and sex-matched controls. Gastroscopy was performed to start enteral levodopa (L-dopa) therapy in cases and for diagnostic purposes in controls (gastroesophageal reflux, anemia, and abdominal pain were the main indications). The clinical definition of cases and controls was made a priori. Six controls had data suggestive of "mild presymptomatic parkinsonism". Biopsy specimens were immunostained for α-synuclein. The neuropathological diagnosis was established post hoc. No differences were found in the baseline characteristics of the groups. Positive fibers for the α-synuclein protein were observed in 17 of 28 (60.7%) Parkinson's disease patients, 1 of 23 controls (4.3%), and 1 of 6 (16.7%) cases of incident "mild presymptomatic parkinsonism." Neuropathological diagnosis based on α-synuclein immunostaining showed a sensitivity of 85% (95% confidence interval [CI] 62.1-96.8), specificity of 95% (95% CI 76.2-99.9) and area under the receiver operating characteristics curve (AUC) of 0.90 (95% CI 0.80-1.00). No adverse events occurred. Detection of α-synuclein inclusions in the gastric mucosa is a useful and safe tool providing in vivo evidence of the underlying neurodegenerative peripheral involvement linked to Parkinson's disease. Further studies are warranted to determine its pathophysiological implications.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Alvarez Santullano, Marina Mata" sort="Alvarez Santullano, Marina Mata" uniqKey="Alvarez Santullano M" first="Marina Mata" last="Álvarez-Santullano">Marina Mata Álvarez-Santullano</name><name sortKey="Catalan, Maria Jose" sort="Catalan, Maria Jose" uniqKey="Catalan M" first="María José" last="Catalán">María José Catalán</name><name sortKey="Fernandez Diez, Servando" sort="Fernandez Diez, Servando" uniqKey="Fernandez Diez S" first="Servando" last="Fernández Díez">Servando Fernández Díez</name><name sortKey="Garcia Cobos, Elvira" sort="Garcia Cobos, Elvira" uniqKey="Garcia Cobos E" first="Elvira" last="García-Cobos">Elvira García-Cobos</name><name sortKey="Herreros Rodriguez, Jaime" sort="Herreros Rodriguez, Jaime" uniqKey="Herreros Rodriguez J" first="Jaime" last="Herreros-Rodríguez">Jaime Herreros-Rodríguez</name><name sortKey="L Pez Lozano, Juan Jose" sort="L Pez Lozano, Juan Jose" uniqKey="L Pez Lozano J" first="Juan José" last="L Pez-Lozano">Juan José L Pez-Lozano</name><name sortKey="L Pez Manzanares, Lydia" sort="L Pez Manzanares, Lydia" uniqKey="L Pez Manzanares L" first="Lydia" last="L Pez-Manzanares">Lydia L Pez-Manzanares</name><name sortKey="L Pez Valdes, Eva" sort="L Pez Valdes, Eva" uniqKey="L Pez Valdes E" first="Eva" last="L Pez-Valdés">Eva L Pez-Valdés</name><name sortKey="Molina Arjona, Jose Antonio" sort="Molina Arjona, Jose Antonio" uniqKey="Molina Arjona J" first="José Antonio" last="Molina-Arjona">José Antonio Molina-Arjona</name><name sortKey="Mosqueira, Antonio J" sort="Mosqueira, Antonio J" uniqKey="Mosqueira A" first="Antonio J" last="Mosqueira">Antonio J. Mosqueira</name><name sortKey="Rabano, Alberto" sort="Rabano, Alberto" uniqKey="Rabano A" first="Alberto" last="Rábano">Alberto Rábano</name><name sortKey="Rodriguez Valcarcel, Fernando Canga" sort="Rodriguez Valcarcel, Fernando Canga" uniqKey="Rodriguez Valcarcel F" first="Fernando Canga" last="Rodríguez-Valcárcel">Fernando Canga Rodríguez-Valcárcel</name><name sortKey="Sanchez Sanchez, Rafael" sort="Sanchez Sanchez, Rafael" uniqKey="Sanchez Sanchez R" first="Rafael" last="Sánchez-Sánchez">Rafael Sánchez-Sánchez</name><name sortKey="Vela Desojo, Lydia" sort="Vela Desojo, Lydia" uniqKey="Vela Desojo L" first="Lydia" last="Vela Desojo">Lydia Vela Desojo</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Sanchez Ferro, Alvaro" sort="Sanchez Ferro, Alvaro" uniqKey="Sanchez Ferro A" first="Álvaro" last="Sánchez-Ferro">Álvaro Sánchez-Ferro</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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